TMCnet

Addex Announces Publication of Preclinical Data Supporting Potential of mGlu7 Negative Allosteric Modulators to Transform Anxiety and Fear-Related Disorder Treatment

Ciobanu, A.C., Caseiro, D.M., Niu, R. et al. Negative allosteric modulation of mGlu7 disrupts fear memory reconsolidation and glutamatergic signaling in rat and human brain tissue. Mol Psychiatry ...
sciencex

Allosteric modulation of G-protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

A publication from Acta Pharmaceutica Sinica B discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a debilitating ...
Healio

Allosteric modulator nonsuperior to placebo in Parkinson’s disease

Please provide your email address to receive an email when new articles are posted on . Change from baseline in gait variability did not differ between groups, regardless of cognitive load. Treatment ...
Monthly Prescribing Reference

Negative Allosteric Modulator Gets Fast Track Status for Social Anxiety Disorder

The Company will evaluate BNC210 in patients with SAD in the phase 2 PREVAIL trial. The Food and Drug Administration (FDA) has granted Fast Track designation to BNC210 for the acute treatment of ...
BioWorld

Neumora’s M4 receptor positive allosteric modulator enters clinic for schizophrenia

Neumora Therapeutics Inc. has announced IND clearance and initiation of a phase I study of NMRA-266 in healthy adults. NMRA-266 is a highly selective positive allosteric modulator of the muscarinic ...
EurekAlert!

Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

This new article publication from Acta Pharmaceutica Sinica B, discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a ...