Two rare mutations in the APOE gene ― APOE ε4 (R251G) and APOE ε3 (V236E) ― dramatically reduce the risk of developing Alzheimer's disease (AD), results of a large genetic association study show. APOE ...

Two genome-wide association studies together report three new susceptibility loci for late-onset Alzheimer’s disease. CLU, PICALM and CR1 may be involved in amyloid-β clearance from the brain.

ApoE research is not just about its three main alleles. You may have heard the words Christchurch and Jacksonville in connection with ApoE, but did you know that well over 100 variants have been ...

See Part 5 and Part 6 of this series. Most amyloid fibrils in the human body are toxic, but a select few perform important functions. What sets them apart? At the Society for Neuroscience annual ...

When the results are analyzed in terms of relative risk, as done by Farrer and colleagues, [4] the APOE4 allele was found associated with an increased risk of AD, whereas the E2 allele appeared to ...

Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the ...

Despite the identification of the APOE gene as the strongest genetic link to late-onset Alzheimer's disease (AD) since 1993 and the subsequent advances in the understanding of AD pathogenesis, the ...

Latin name: Ovis aries. Breed is unknown. Sheep are the most widely distributed domestic animal around the world. There are more than 200 breeds and they are raised for their wool, meat and milk. This ...

Please provide your email address to receive an email when new articles are posted on . The APOE e4 allele correlated with earlier clinical and biomarker-related changes of Alzheimer’s disease among ...

A recent study published in Alzheimer’s Research & Therapy examined the long-term subjective cognitive decline risk associated with Herpes zoster infections. It investigated whether the association ...