The terms "intestinal barrier" and "intestinal permeability" describe two different aspects of the same anatomical structure, the intestinal wall composed of four layers, the mucosa, the submucosa, ...

Altered intestinal barrier function is postulated to be a central predisposing factor to intestinal diseases, including inflammatory bowel diseases and food allergies. However, the mechanisms involved ...

There is a critical unmet need to help tighten and maintain a healthy intestinal barrier and treat a leaky gut. Researchers have now found that a unique strain of probiotic bacteria, Bifidobacterium ...

EVER since Réaumur, more than two centuries ago, discovered that gastric juice digests meat, men have asked: "Why doesn't the stomach digest itself?" There are two answers to this question. One is, of ...

The study, published in Nature Biotechnology, highlights the role of Chemistry42 and its submodules in supporting drug candidate design and optimization. The research underscores the potential of ...

The intestinal mucosa absorbs nutrients, water, and electrolytes in a controlled manner–while simultaneously keeping out toxins, allergens, and some bacteria. When this barrier is damaged, it is ...

An international research team led by scientists from Bern and Charité - Universitätsmedizin Berlin has identified a previously unknown function of the intestinal nervous system. The study reveals ...

A research team from POSTECH and ImmunoBiome in Korea, led by Professor Sin-Hyeog Im, has uncovered a new mechanism showing ...

Patients who have undergone pelvic radiotherapy may live with low-grade chronic inflammation of the lower intestine 20 years after the treatment. This has been shown in a study by researchers at the ...

-- The study presents the journey of designing and optimizing novel gut-restricted PHD inhibitors using the comprehensive generative chemistry engine Chemistry42. -- From initiation to preclinical ...