Mitochondria are known as the body’s “energy factories,” and their function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system ...
Mitochondria are the body's "energy factories," and their proper function is essential for life. Inside mitochondria, a set of complexes called the oxidative phosphorylation (OxPhos) system acts like ...
Figure 1 BET inhibition is synthetic lethal to OXPHOS blockage in liver cancer. Left: GDH1-dependent glutamine metabolic remodeling upon BET inhibition. Right: “Synthetic lethality” targeting OXPHOS ...
Marina Rosa Moreno, Fátima Sánchez Cabo, José Luis Cabrera, José Antonio Enríquez, María Concepción Jiménez, Pablo Hernansanz Agustín and Lucía Sánchez-García. Mitochondria are the body’s “energy ...
New findings in mice suggest it’s possible to prevent organ damage from COVID-19 with an antioxidant enzyme that protects a cell’s mitochondria without the risk of resistance. The study that led to ...
Treatment resistance remains a major challenge in the treatment of acute myeloid leukemia (AML), and leveraging actionable therapeutic targets is far from straightforward. The investigators began by ...
Sarcomas are generally classified into soft tissue sarcomas, such as fibrosarcoma, and bone sarcomas such as chondrosarcoma, which are rare cancers in adults accounting for about 1% of all cancer ...
Revolutionary imaging technique uncovers metabolic differences in ovarian cancer subtypes, paving the way for early detection and personalized treatment strategies. Study: Metabolic imaging ...
Researchers from Sichuan University synthesized new pyrazole amides based on the previously described NADH-ubiquinone oxidoreductase (complex I, CI) inhibitor IACS-010759. Subsequent optimization ...
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