Observational research is core to drug development, helping researchers understand the natural history of diseases and the real-world impact of treatments on patients. Observational studies frequently ...

• Accounting for bias is a major challenge confronting the use of observational data to gain important insights into real-world treatment effects. • No single study design will satisfy all information ...

Where can observational studies be registered? An increasing number of clinical trial registries exist and, despite their names, some include observational studies ...

Rachael L. Fleurence ( [email protected]) is a senior research scientist and director of the Evidence Review and Synthesis Practice, United BioSource Corporation, in Bethesda, Maryland. Huseyin Naci ...

The pharmaceutical industry is facing growing pressure to make drug development more patient-focused. Traditionally, most observational research has been derived from clinical and payer data, but has ...

Comparative effectiveness research increasingly is being recognized as a priority area in cancer research. Although researchers have been conducting comparative effectiveness research for decades, ...

Statisticians point out that medical and other observational studies often produce results that are later shown to be incorrect. They now suggest ways to fix the system. S. Stanley Young, assistant ...

Would you volunteer to become vegetarian for the next three decades for the sake of science? What if you were asked to run at least 50 kilometres per week, or live through a natural disaster? Granted, ...