Rather than completely blocking all downstream signals, the peptide developed in this study focuses on inhibiting the activation of p38-MAPK. This is enough to downregulate the development of mature ...

Three water-soluble egg yolk fractions (FA, FB, and FC) and subfractions of FC (FC1 (< 3 kDa) and FC2 (> 3 kDa)) showed promising osteoclastogenesis inhibitory effects by suppressing osteoclast ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. This ...

Throughout our lives, our bones are continuously remodeled to maintain strength, repair injuries and adapt to new stresses. Bone dynamics depend on two associated cell types: osteoblasts, which are ...

Female ginseng has long been used in traditional Chinese medicine for osteoporosis treatment. A new compound that affects osteoclast formation has been derived from the plant Angelica sinensis, ...

A team from the Medical University of Vienna, in Austria, has successfully developed an algorithm within the StrataQuest image analysis software that can automatically detect and quantify osteoclasts.

Osteocytes, the most abundant cells in bone tissue, have long been underestimated in their functional capacity. Traditionally viewed as passive entities, recent research has illuminated their pivotal ...