Bioprocessors must minimize the aggregation of therapeutic proteins, but that’s not an easy task. Proteins can aggregate during any step from manufacturing to administering a drug. “The aggregation ...
PTIR calculates the rates at which originally monomeric proteins are transformed into aggregates at various temperatures under initial-rate settings. Utilizing SMSLS for identical conditions generates ...
A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates found in Alzheimer's disease, pointing toward a new potential therapeutic ...
The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington’s, Alzheimer’s and Parkinson’s. But to the human eye, proteins that are ...
A technique that can detect and measure small protein aggregates, which are hallmarks of numerous neurodegenerative diseases, has been developed. Protein aggregation – when proteins misfold and clump ...
Top left shows how the in vitro aggregation of the protein TDP-43 (associated with ALS), seen as white blobs, is dependent on the concentration of ATP (measured in millimolar, mM). The same is shown ...
The COVID-19 pandemic brought about by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) led to the disruption of the global economy and the loss of human lives. Studies are still ...
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