When replication forks collapse, Rad3 phosphorylates the checkpoint-clamp protein Rad9 in a manner that depends on Thr 225, a residue within the PCNA-like domain. The physiological function of Thr 225 ...
Talazoparib beyond BRCA: A phase II trial of talazoparib monotherapy in BRCA1 and BRCA2 wild-type patients with advanced HER2-negative breast cancer or other solid tumors with a mutation in homologous ...
Nucleases can cleave stalled forks, causing double-strand breaks (DSBs) to form and activate ataxia-telangiectasia mutated (ATM). The rate at which DSBs form at stalled forks is greatly increased in ...
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