In the cerebral cortex, extrinsic and intrinsic excitatory glutamatergic pathways terminate on principal glutamatergic neurons and local inhibitory GABAergic interneurons. Activation of these pathways ...

Roche reported positive Phase II topline data showing that its once-weekly dual glucagon-like peptide-1 and glucose-dependent ...

A bitter taste has always been considered a warning signal, devoted to protecting us from ingesting potentially harmful ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some ...

The paper, titled, "Weekly Subcutaneous VK2735, a GIP/GLP-1 Receptor Dual Agonist, for Weight Management: Phase 2, Randomized, 13-Week VENTURE Study," was published in Obesity, the peer-reviewed ...

Researchers at the University of North Carolina (UNC) at Chapel Hill School of Medicine have revealed the detailed structure of the bitter taste receptor, a protein called TAS2R14, and have shown ...

Prostaglandin E 2 (PGE 2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4. While ...

Epidermal growth factor receptor (EGFR) signaling in the tissue around oral cancers both increases nerve sensitivity and ...

The novel biosensor technology used in this study can also be transferred to other so-called G protein-coupled receptors (GPCRs), which act as crucial “signal receivers” in our cells and are of major ...

Muse Treatment Alcohol & Drug Rehab Los Angeles has published a new educational resource that explains how opioid receptors function in the brain and why they play a central role in pain relief, ...