New research suggests pain is not a simple signal of injury but a process that unfolds across nerves, spinal cord, and brain.

"One region in the thoracolumbar spinal cord was shown to relay noxious information into brainstem pain-related circuits, while the other spinal region in the lumbosacral spinal cord carried a broader ...

Top: An acute spinal cord injury leads to an interruption of motor nerve pathways, resulting in paraplegia, a paralysis of arm and leg muscles. Center: The injured nerve pathways cannot recover ...

Scientists created a model of the human pain pathway in a dish by connecting four separate brain organoids. The feat should help them understand sensory disorders like those affecting pain perception.

A neural circuit hidden in an understudied region of the brain plays a critical role in turning temporary pain into pain that can last months or years, according to new University of Colorado Boulder ...

Scientists have re-created a pain pathway in the brain by growing four key clusters of human nerve cells in a dish. This laboratory model could be used to help explain certain pain syndromes, and ...

Stroke and spinal cord injuries can severely impair motor functions, and understanding how to promote recovery is a critical challenge. While damaged neurons in the brain and spinal cord have limited ...