A holistic inquiry into how toxic tau impacts synapses provides a new take on the processes that lead to neuronal dysfunction ...

Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

Cognitive tasks, such as learning and memory, require rapid changes to proteins at synapses, such as protein synthesis, degradation, and trafficking. How protein post-translational modifications ...

Researchers are testing a new approach to repair early memory loss by protecting brain connections affected in Alzheimer’s ...

A study mapped genes linked to schizophrenia and uncovered a mechanism that disrupts synaptic plasticity in affected individuals. The researchers showed the role of three proteins in mediating the ...

Researchers have found that a natural aging-related molecule can repair key memory processes affected by Alzheimer’s disease.

Recently, researchers from the University of Queensland (Australia) and the Wicking Dementia Research and Education Centre at the University of Tasmania investigated the effects of rTMS on synapses in ...

Li’s study, “TIAM1-mediated synaptic plasticity underlies comorbid depression-like and ketamine antidepressant-like actions in chronic pain," was recently published in The Journal of Clinical ...

As animals experience new things, the connections between neurons, called synapses, strengthen or weaken in response to events and the activity they cause in the brain. Neuroscientists believe that ...

For much of the 20th century, scientists believed that the adult human brain was largely fixed. According to this view, the ...

Ageing is not a purely degenerative phenomenon, but a dynamic process involving biological, experiential and environmental factors. This is the result of two different projects conducted at SISSA as ...