Kent Rollins on MSN

Cheese fries loaded with bacon the Ranch Kitchen way

This dish starts with thick-cut steak fries cooked until crisp on the outside and tender through the middle. Cooking them in cast iron matters because steady heat helps the potatoes brown without ...
eLife

A proteome-wide biochemical screen defines binding determinants of the core autophagy protein LC3B

Human MAP1LC3B (LC3B) binds proteins involved in autophagy and other cellular processes using a degenerate four-residue short linear motif known as the LC3-interacting region (LIR). Biochemical and ...

A landmark 'evolutionary double-bind' strategy to overcome treatment resistance in prostate cancer

Many patients with metastatic cancers receive therapy that is initially highly effective, often resulting in complete remission. However, cancer cells have a remarkable capacity to evolve resistance ...
InfoQ

Microsoft Agent Framework RC Simplifies Agentic Development in .NET and Python

Microsoft has announced that the Microsoft Agent Framework has reached Release Candidate status for both .NET and Python. This milestone indicates that the API surface is stable and feature-complete ...
Communications of the ACM

A Decade of Docker Containers

Docker is a widely used developer tool that first simplifies the assembly of an application stack (docker build), then allows for the rapid distribution of the resulting executabl ...
eLife

TAD boundary architecture and gene activity are uncoupled

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...