Clostridioides difficile, formerly known as Clostridium difficile, is a gram-positive and spore-forming bacterium. This obligate anaerobic bacillus is recognized for its ability to produce toxins and cause diarrhea, which is often associated with antibiotic usage. Although traditionally considered a primary healthcare-associated infection, C difficile is also increasingly diagnosed within community settings. The emergence of the newer, hypervirulent, antibiotic-resistant, epidemic strain—ribotyp

Antibiotics for Clostridioides difficile infection can induce microbiome disruption that facilitates germination of C. difficile spores, so a two-pronged treatment approach is needed. New research findings are summarized in a short video. https://nej.md/3KiucC1 | The New England Journal of Medicine