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Dexmedetomidina: la sedación que imita el sueño fisiológico. A diferencia de otros sedantes, actúa inhibiendo el locus coeruleus, disminuye la noradrenalina y genera un patrón EEG similar al sueño NREM fase 2 (sleep spindles 12–16 Hz). 🔹 Sedación “despertable” y cooperativa 🔹 Preserva la función respiratoria 🔹 Menor incidencia de delirium 🔹 Favorece arquitectura de sueño más fisiológica 📊 Mientras: Propofol → patrón tipo anestesia Midazolam → actividad beta desorganizada Dexmedetomidina → s
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